Olfactory and Trigeminal Pathways That Carry Lipid Nanoparticles From Nasal Epithelium to Brain Reward Circuits and Dementia Targets
Intranasal lipid nanoparticles could deliver GLP-1 drugs to brain reward and dementia circuits.
Tobias Mehring
Section
Nanoparticle Carriers
12 stories in Nanoparticle Carriers.
How Columbia University Built a 30-Year Nanoparticle Patent Estate That Defines Peptide Delivery Platform Science
Foundational polymer chemistry and 30 years of research built a defensible delivery platform.
Séverine Okafor
Why Large-Molecule Peptides Require Nanoparticle Encapsulation to Survive the Nasal-to-Brain Transit
Nasal nanoparticles shield peptides from clearance, enzymatic attack, and epithelial barriers.
Tobias Mehring
Proprietary Nanoparticle IP Estates That Enable Nose-to-Brain Peptide Delivery at the Route Level
Nanocarrier IP protects how peptides reach the brain, not just the molecules themselves.
Marcus Tully-Byrne
Nanoparticle Platforms in Clinical and Preclinical Development for Intranasal CNS Delivery
Lipid and polymeric carriers show the most promise for delivering brain drugs through the nose.
Priya Venkatesan
University Spinouts With Foundational Patent Estates in Nanoparticle Peptide Delivery
University spinouts may control GLP-1 delivery through foundational nanoparticle patents.
Marcus Tully-Byrne
Nanoparticle Size and Zeta Potential Effects on in Vivo Behavior
Tuning particle size and charge unlocks direct brain delivery through nasal routes.
Tobias Mehring
Nanoparticle Scale-Up From Lab Bench to GMP Manufacturing
Controlling particle physics, not just batch volume, keeps nanoparticles consistent at scale.
Tobias Mehring
Exosome and Extracellular Vesicle Platforms for CNS Peptide Delivery
Exosomes could deliver brain peptides by mimicking cells' natural transport.
Marcus Tully-Byrne
Regulatory Classification of Nanoparticle Drug Products at the FDA
The FDA uses existing drug and biologic frameworks to evaluate nanoparticle products.
Priya Venkatesan
Nanoparticle Surface Functionalization for Blood-Brain Barrier Crossing
Ligand choice and particle chemistry must match the barrier's biology to reach the brain.
Séverine Okafor
Lipid Nanoparticle Formulation Variables and Peptide Encapsulation Efficiency
Peptide cargo requires different lipid formulation rules than the mRNA vaccines that came before.
Tobias Mehring